A cooperative polymeric platform for tumor-targeted drug delivery† †Electronic supplementary information (ESI) available: Materials, experimental description of preparation of FITC-labeled fibrinogen, histopathological analyses at varied doses of DMXAA, preparation of RhoB- and IR830-labeled A15-PGA-CisPt, characterization of the prepared A15-PGA-CisPt conjugates, in vitro release, cytotoxicity, cellular uptake, stability test in plasma, and pharmacokinetic test. Schemes of syntheses of RhoB- or IR830-labeled PGA-g-mPEG/MAL-PEG, macroscopic observation of hemorrhages, histopathological analysis of fibrin localization, H&E and histopathological analysis of heart, liver, spleen, lung and kidney, 1H NMR spectrum and GPC curves of PGA-g-mPEG/MAL-PEG, DLS, TEM image, XPS spectra, in vitro release, cytotoxicity, CLSM images of cellular uptake, sizes and surface bound proteins measurement, pharmacokinetic results, UV-spectrum of IR830-labeled A15-PGA-CisPt in water, platinum biodistribution. See DOI: 10.1039/c5sc01698c Click here for additional data file.
نویسندگان
چکیده
Key Laboratory of Polymer Ecomaterials, C Chinese Academy of Sciences, Changchun, 1 ac.cn; [email protected] Research Center for Drug Metabolism, C Changchun, 130012, P. R. China † Electronic supplementary information description of preparation of FITC-l analyses at varied doses of DMXAA, pre A15-PGA-CisPt, characterization of the p vitro release, cytotoxicity, cellular upt pharmacokinetic test. Schemes of sy PGA-g-mPEG/MAL-PEG, macroscopic histopathological analysis of brin loc analysis of heart, liver, spleen, lung and curves of PGA-g-mPEG/MAL-PEG, DLS, TE cytotoxicity, CLSM images of cellular upt measurement, pharmacokinetic resul A15-PGA-CisPt in water, platinum biodist Cite this: Chem. Sci., 2016, 7, 728
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